23rd Annual Scientific Sessions:

Aging as a Gateway to Cardiovascular-Metabolic Research

Osaka, Japan 26-29 October 2026

23rd Annual Scientific Sessions:

Aging as a Gateway to Cardiovascular-Metabolic Research

Osaka, Japan 26-29 October 2026

23rd Annual Scientific Sessions:

Aging as a Gateway to Cardiovascular-Metabolic Research

Osaka, Japan 26-29 October 2026

Programme

Programme

  • 10:00-17:00

    Registration

    9:00-11:00

    SHVM Board Meeting (for board members only)

    Professional Development Session (sponsored by Keyence)

    Chairs: Kaitlyn Dennis (Oxford, UK) and Bellina Mushala (Pittsburgh, PA, USA)

    Session 1: Meet the Editors

    11:00-11:40

    Introduction and panel discussion
    Nature Reviews Cardiology, Journal of Molecular and Cellular Cardiology, JAMA Cardiology, Cardiovascular Research

    Gregory Lim, Junichi Sadoshima, Barbara Casadei, Tomasz Guzik, Joe Ross

    11:40-12:40

    Speed mentoring with the editors + board member editors

    12:40-13:05

    Break

    Session 2: International collaborations in science

    13:05-13:15

    Norika Liu (Kumamoto, Japan)
    Building international collaborations as an early-career researcher

    13:15-13:25

    Miranda Nabben (Maastricht, The Netherlands)

    13:25-13:35

    E. Dale Abel (Los Angeles, CA, USA)

    13:35-14:00

    Panel Discussion

    Opening Session

    14:00-14:15

    Welcome from Organisers and SHVM President

    14:15-15:05

    Plenary Lecture

    Chairs: Luc Bertrand (Brussels, Belgium), Natsuko Tsurudome (Osaka, Japan)

    Masashi Yanagisawa (Tsukuba, Japan)
    Deciphering the mysteries of sleep: from fundamental neuroscience to real-world applications

    15:05-15:25

    Break

    15:25-16:00

    Evening seminar (sponsored by Keyence)

    Chairs: Yoshimitsu Yura (Nagoya, Japan), Luís Grilo (Cantanhede, Portugal)

    Introduction by Keyence

    Satoru Takahashi (Tsukuba, Japan)
    Elucidation of skeletal muscle regulation mechanisms using mouse space experiments on the international space station (ISS)

    Keynote Lectures

    Chairs: Hyoung Kyu Kim (Busan, Republic of Korea), Atsuko Okazaki (Tokyo, Japan)

    16:10-16:40

    Masaru Ishii (Osaka, Japan)
    Spatiotemporal heterogeneity of in vivo immune systems elucidated by intravital optical imaging technologies

    16:40-17:10

    Simon Sedej (Graz, Austria)
    TBD

    17:45

    Bus to the dinner venue

    18:30

    Dinner: The Landmark Square Osaka

  • Session 1 • Aging, Redox Signaling, and Metabolic Stress in the Cardiovascular System

    Chairs: Jin Han (Busan, Republic of Korea), Thomas Pulinilkunnil (Saint John, Canada)

    8:30-8:55

    Cholsoon Jang (Irvine, CA, USA)
    Tracing metabolic flux and nutrient exchange between organs during aging

    8:55-9:20

    Philip Eaton (London, UK)
    Redox signaling and protein oxidation in cardiovascular adaptation

    9:20-9:45

    Ichiro Manabe (Chiba, Japan)
    Immunometabolic regulation of inflammation and fibrosis in the heart

    9:45-10:10

    Geneviève Derumeaux (Paris, France)
    Advanced cardiac imaging to detect and monitor cardiac aging

    10:10-10:22

    Short talk: Megan Young (London, United Kingdom)
    Does NLRP3 couple metabolic stress to cardiac dysfunction in diabetic cardiomyopathy?

    10:22-10:42

    Break

    Session 2 • Metabolic Remodeling and Energetic Control in the Failing Heart

    Chairs: Keiji Kuba (Fukuoka, Japan), Jaetaek Kim (Seoul, Republic of Korea)

    10:42-11:07

    Junichi Sadoshima (Newark, NJ, USA)
    Autophagy and mitochondrial quality control in the heart

    11:07-11:32

    Christophe Beauloye (Brussels, Belgium)
    Metabolic signatures of heart failure

    11:32-11:57

    Dunja Aksentijevic (London, UK)
    Metabolic imaging of the failing heart: from energy metabolism to therapeutic targets

    11:57-12:09

    Short talk: Qutuba Karwi (St. John’s, Canada)
    Decoding ventricular differences: UCP2 as a modulator of cardiac oxidative Metabolism and Ca2+ homeostasis

    12:20-13:10

    Luncheon Seminar (sponsored by Shimadzu)

    Chair: Motohiro Nishida (Fukuoka, Japan)

    Takaaki Akaike (Miyagi, Japan)
    Discovery of cyclic octasulfur as an emerging supersulfide in mammals and humans

    13:10-13:30

    Break

    13:30-14:20

    Plenary Lecture

    Chair: Julie Rennison (Cleveland, OH, USA), Mark Emile Pepin (Stanford, CA, USA)

    Barbara Casadei (London, UK)
    Atrial fibrillation: rethinking mechanisms, reimagining care

    14:20-14:30

    Break

    14:30-15:10

    Evening seminar (sponsored by Bristol Myers Squibb)

    Chairs: Takanori Yamaguchi (Saga, Japan)

    Yuichi Shimada (New York, NY, USA)
    Efficacy and safety of cardiac myosin inhibitors in hypertrophic cardiomyopathy: insights from randomized controlled trials and real-world clinical experience in the United States

    Session 3 • The “William C. Stanley” Early Investigator Awards

    Chair: Rebecca Ritchie (Parkville, Australia), Martin Young (Birmingham, AL, USA)

    15:10-15:25

    Rita Alonaizan (Riyadh, Saudi Arabia)
    A balanced circadian glycolytic rhythm drives cardiomyocyte cell cycle progression during fish heart regeneration

    15:25-15:40

    Jayd Dayaram (Auckland, New Zealand)
    Uncovering novel mechanism-directed therapies for cardiometabolic heart failure with preserved ejection fraction

    15:40-15:55

    Jae Woo Jung (Philadelphia, USA)
    One carbon metabolism defect in human failing hearts

    15:55-16:10

    Aaron Jiashuo Zhang (Oxford, United Kingdom)
    Epigenetic reprogramming via dysregulated H3K9 trimethylation drives cardiac energetic dysfunction in type 2 diabetes

    16:10-18:10

    Poster Session I (sponsored by JMCC, AJP: Heart Circ Physiol, Nat Rev Card, and Springer)

    18:30

    Bus to the dinner venue

    19:00

    Dinner: Jambo Tsuribune Tsurikichi

  • Session 4 • Organ-to-organ communication in aging

    Chair: Yasutomi Higashikuni (Osaka, Japan)

    8:30-8:55

    Jane Reznick (Cologne, Germany)
    Systemic metabolic coordination and inter-organ adaptation during aging

    8:55-9:20

    José Javier Fuster (Madrid, Spain)
    Vascular inflammation and metabolic crosstalk in age-related diseases

    9:20-9:45

    Peter Liu (Ottawa, Canada)
    From mechanisms to medicine: translational strategies for the aging heart

    9:45-9:57

    Short talk: Alireza Saadatmand (Dossenheim, Germany)
    CaMKII regulates cardiac metabolic substrate switching during heart failure

    9:57-10:09

    Short talk: Tin May Aung (Osaka, Japan)
    PCPE-1 promotes renal fibrosis with aging and cardiorenal syndrome in chronic kidney disease

    10:10-10:30

    Break

    Session 5 • Inflammation, Fibrosis and Cardiac Remodelling

    Chairs: Mahmoud Abdellatif (Graz, Austria), Wataru Kimura (Kobe, Japan)

    10:30-10:55

    Hyun Kook (Gwangju, Republic of Korea)
    Molecular mechanisms linking protein posttranslational modifications to cardiac remodeling

    10:55-11:20

    Melanie Madhani (Birmingham, UK)
    Kinase signaling pathways driving cardiac inflammation and remodeling

    11:20-11:45

    Shujin Wang (Chongqing, China)
    Vacuolar H+-ATPase restrains cardiac aging through rewiring cardiolipin metabolism

    11:45-11:57

    Short talk: Alice Marino (Brussels, Belgium)
    Unlocking the role of myo-inositol/SMIT1 axis in cardiometabolic HFpEF

    11:57-12:09

    Short talk: Nguyen Tran (Seoul, Republic of Korea)
    GDH-driven anaplerosis restores diastolic function in HFpEF mice by refueling the TCA cycle

    12:10-12:30

    Break

    12:30-13:20

    Luncheon Seminar

    Chairs: Tomoya Kitani (Kyoto, Japan), Aaron Jiashuo Zhang (Oxford, United Kingdom)

    Masanori Nakayama (Kanjin Therapeutics Inc)
    Discovery and development of first-in-class drugs to cure chronic kidney disease [30 min]

    Simiao Zhao (Eonark Biotech Co., LTD)
    AI-Driven identification of conserved metabolic aging regulators using single-cell data [10 min]

    13:20-13:50

    Break

    Session 6 • Sex differences in metabolism and CVD

    Chairs: Véronique A. Lacombe (Stillwater, OK, USA), Gabriele G. Schiattarella (Berlin, Germany)

    13:50-14:15

    Ylva Hellsten (Copenhagen, Denmark)
    Vascular and metabolic adaptations to exercise: insights into sex differences

    14:15-14:40

    Kenneth Walsh (Charlottesville, VA, USA)
    Sex chromosomes, clonal hematopoiesis, and cardiometabolic disease

    14:40-15:05

    Miranda Nabben (Maastricht, The Netherlands)
    TBD

    15:05-15:17

    Short talk: Mikky Atser (Vancouver, Canada)
    Cardiac pyruvate dehydrogenase kinase 1 knockout remodels cardiomyocyte cytoskeletal structure and decreases fatty acyl availability in female mice

    15:17-15:29

    Short talk: Tayla Bishop (Melbourne, Australia)
    Divergent sex- and ligand-specific effects of soluble guanylate cyclase (sGC) modulators on blood pressure and exercise capacity in a preclinical mouse model of heart failure with preserved ejection fraction (HFpEF)

    15:30-15:45

    Photo time and Break

    15:45-17:45

    Poster Session II (sponsored by JMCC, AJP: Heart Circ Physiol, Nat Rev Card, and Springer)

    18:20

    Bus to the dinner venue

    18:30-21:00

    Gala dinner: "The Korin" Rihga Royal Hotel Osaka (East/Tower Wing 3F)

  • 8:30-9:30

    "William C. Stanley" Award Lecture

    Chairs: E. Dale Abel (Los Angeles, CA, USA), Jan F.C. Glatz (Maastricht, The Netherlands)

    Terje Larsen (Tromsø, Norway)
    Fatty acid-induced loss of cardiac efficiency in obesity

    9:30-10:00

    Break

    Session 7 • Cutting-edge approaches to study and treat the aging heart

    Chairs: Andrew Murray (Cambridge, United Kingdom), Laurent Bultot (Osaka, Japan)

    10:00-10:25

    Yibin Wang (Singapore)
    Systems biology and multi-omics approaches to decode cardiac aging

    10:25-10:50

    Joo-Mi Yi (Busan, Republic of Korea)
    Epigenetic modifications as therapeutic targets in cardiac aging

    10:50-11:15

    Li Qian (Chapel Hill, NC, USA)
    Cardiac reprogramming and regenerative strategies for the failing heart

    11:15-11:27

    Short talk: Kim Mellor (Auckland, New Zealand)
    Targeting fructose metabolism in the heart rescues diastolic function in cardiometabolic disease

    11:27-11:39

    Short talk: Hideki Uosaki (Shimotsuke, Japan)
    A patient-derived iPSC library of mitochondrial cardiomyopathy identified beneficial effects of taurine to KARS mutations

    11:40-12:00

    Invitation to SHVM 2027

    12:00-13:00

    Lunch (take out style)

    SHVM and Korea BCS Session 1

    Chairs: Byung Jin Kim (Seoul, Republic of Korea), Klaudia Stawarska (Gdańsk, Poland)

    13:00-13:25

    Adam Wende (Birmingham, AL, USA)
    Metabolic reprogramming and redox regulation in heart failure

    13:25-13:50

    Hun-Jun Park (Seoul, Republic of Korea)
    Spatiotemporal immune modulation to reverse post-MI adverse remodeling

    13:50-14:15

    Nobuyuki Takakura (Osaka, Japan)
    Endothelial cell niches and vascular–cardiac crosstalk in tissue homeostasis

    14:15-14:27

    Short talk: Konstantinos Lekkos (Oxford, United Kingdom)
    The mitochondrial NAD+ transporter slc25a51b modulates heart regeneration and morphogenesis

    14:27-14:39

    Short talk: Rachel Crawford (Iowa City, IA, USA)
    Fuel to force: A novel ex vivo method for assessing glucose- and fatty acid-supported force generation as an index of ATP production in myocardial slices

    14:40-15:00

    Break

    SHVM and Korea BCS Session 2

    Chairs: Hun-Jun Park (Seoul, Republic of Korea), Alexa King (Edmonton, Canada)

    15:00-15:25

    Luc Bertrand (Brussels, Belgium)
    Metabolic signaling and cardiac remodeling under stress conditions

    15:25-15:50

    Sung Woo Cho (Goyang, Republic of Korea)
    Angiotensin-converting enzyme 2 activation in diabetic cardiomyopathy

    15:50-16:15

    Yong Joo Ahn (Pohang, Republic of Korea)
    Gestational diabetes reprograms the placenta–fetal heart axis toward accelerated cardiovascular aging

    16:15-16:27

    Short talk: Eline Stukkens (Brussels, Belgium)
    Hyperacetylation comes first: an early event preceding cardiac insulin resistance and functional decline in diet-induced diabetic cardiomyopathy

    16:27-16:39

    Short talk: Liming Pei (Philadelphia, PA, USA)
    A spatiotemporal multidimensional human heart atlas reveals underlying mechanisms of human heart disease progression

    16:40

    Concluding Remarks

    17:30

    Meet in the lobby (Rihga Royal Hotel Osaka)

    18:00

    Final Highlight Event: The Public Plum Umeda
    Join the Chair’s Favorite Bar – An Unofficial Closing Night

    Please see also the SHVM NCVC Satellite Symposium on 30 October

  • When preparing your poster, please remember that its maximum size is A0 (841 x 1189 mm; width x height). Note that the orientation is portrait, not landscape.

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    Poster presenters are required to be available for discussion during their assigned session. The distribution of posters in the two sessions is indicated below.

    Participants may set up their posters from the morning of their assigned presentation day.

    Posters can remain on display throughout the day and during the assigned poster session. They should be removed by the presenters immediately after the session.

    Any posters left behind after the session may be removed and disposed of by the next day's presenters or by the conference secretariat.

    • Poster Session I • Tuesday, 27 October • 16:10-18:10

      P1.1 · Kamaldeen Olalekan Abdullahi (Daegu, Republic of Korea)
      Pharmacological inhibition of pyruvate dehydrogenase kinase 4 improves insulin sensitivity in diabetes and obesity-associated metabolic dysfunction

      P1.2 · Soo Yeon An (Seoul, Republic of Korea)
      Transcriptomic and functional profiling reveals systemic APE1/Ref-1 deficiency predisposes aortas to dystrophic calcification via mTORC1-Aautophagy dysregulation

      P1.3 · Mikky Atser (Vancouver, Canada)
      Cardiac pyruvate dehydrogenase kinase 1 knockout remodels cardiomyocyte cytoskeletal structure and decreases fatty acyl availability in female mice

      P1.4 · Will Banyard (Oxford, United Kingdom)
      Diabetes-associated S-acylation of sarcomeric proteins as a novel mechanism in diabetic cardiomyopathy

      P1.5 · Bini Biswas (Deagu, Republic of Korea)
      Fursultiamine mitigates vascular calcification by targeting Drp1-mediated mitochondrial fission and mitochondrial dysfunction

      P1.6 · Huges Boel (Montréal, Canada)
      EZH2 inhibition attenuates adverse remodeling and drives sex-specific lipidomic corrections in a mouse model of non ischemic heart failure

      P1.7 · Laurent Bultot (Osaka, Japan)
      A spontaneous atrial fibrillation mouse model for the evaluation of novel therapies

      P1.8 · Ryan D. Carter (Oxford, United Kingdom)
      High glucose, healthy fish: mexican cavefish uncouple hyperglycaemia from diabetic pathology

      P1.9 · Kae Won Cho (Cheonan, Republic of Korea)
      Targeting the ApoB100-ENO1 axis with a novel peptide ameliorates atherosclerosis by reducing residual vascular inflammation

      P1.10 · Rachel M. Crawford (Iowa City, IA, U.S.A.)
      Fuel to force: A novel ex vivo method for assessing glucose- and fatty acid-supported force generation as an index of ATP production in myocardial slices

      P1.11 · Chloé David (Montréal, Canada)
      The cardioprotective benefits of B vitamins on cardiac lipidomic remodeling in female mice with heart failure rely on their synergy with 17β-estradiol

      P1.12 · Miles De Blasio (Melbourne, Australia)
      The novel HDAC inhibitor tasquinimod improves markers of diabetic cardiomyopathy in an experimental model of type-1 diabetes

      P1.13 · Manon Denis (Nantes, France)
      O-GlcNAc is a key play to modulate cellular metabolism during stress

      P1.14 · Mariana S. Diniz (Cantanhede, Portugal)
      A2AR stimulation modulate gestational diabesity-derived endothelial progenitor cell mitochondrial features via eNOS

      P1.15 · Matthieu Douard (Pessac, France)
      Basal O-GlcNAcylation is essential to ensure proper electrical activity and calcium handling in ventricular cardiomyocytes

      P1.16 · Keshav Gopal (Edmonton, Canada)
      Late-life restoration of pyruvate dehydrogenase activity reverses cardiac dysfunction in aged obese female mice

      P1.17 · Luís F. Grilo (Cantanhede, Portugal)
      Maternal obesity reprograms sex-specific cardiac early aging trajectories in offspring

      P1.18 · Chae Ryeong Han (Hwasun-gun, Republic of Korea)
      Rbx1 accelerates vascular calcification by targeting Socs3 for ubiquitin-proteasome-dependent degradation

      P1.19 · Ryeon Heo (Seoul, Republic of Korea)
      Interventricular differences in cytosolic calcium buffering under β-adrenergic stimulation

      P1.20 · Lorenz M. W. Holzner (Cambridge, United Kingdom)
      Short-chain acyl-Coenzyme A depletion is a metabolic hallmark of diabetic cardiomyopathy

      P1.21 · Tomoya Ito (Fukuoka, Japan)
      Oxidized glutathione-encapsulating skin-permeable gel prevents postoperative pericardial adhesions and improves cardiac dysfunction

      P1.22 · Agata Jedrzejewska (Gdansk, Poland)
      BCAA supplementation reduces hypoxic injury and improves cardiac energy metabolism in dyslipidemia-associated heart failure

      P1.23 · Jae Woo Jung (Philadelphia, PA, U.S.A.)
      One carbon metabolism defect in human failing hearts

      P1.24 · Patrycja Kaczara (Krakow, Poland)
      Platelet and endothelial remodeling in type 1 diabetes revealed by functional and molecular profiling

      P1.25 · Yuri Kato (Fukuoka, Japan)
      Clomipramine suppresses SARS-CoV-2 infection through sulfide: quinone oxidoreductase-dependent supersulfide metabolism in the heart

      P1.26 · Alexa N. King (Edmonton, Canada)
      Myocardial unsaturated fatty acid oxidation is upregulated in experimental diabetic cardiomyopathy

      P1.27 · Keiji Kuba (Fukuoka, Japan)
      Dissecting the roles of CNOT10 as a key regulator of RNA metabolism in the pathogenesis of dilated cardiomyopathy

      P1.28 · Veronique A. Lacombe (Stillwater, OK, U.S.A.)
      Insulin Receptor Substrate 2 links metabolic dysfunction to altered cardiac responses during influenza A virus infection

      P1.29 · Hoang Phuoc Le (Seoul, Republic of Korea)
      Limited respiratory reserve defines sinoatrial node bioenergetic identity and reveals selective metabolic rescue in HFpEF mice

      P1.30 · Konstantinos Lekkos (Oxford, United Kingdom)
      The mitochondrial NAD+ transporter slc25a51b modulates heart regeneration and morphogenesis

      P1.31 · Fantin Lowenstein (Oxford, United Kingdom)
      Adult-onset of hyperphenylalaninemia promotes atherosclerosis independently of hypercholesterolaemia

      P1.32 · Kim M. Mellor (Auckland, New Zealand)
      Targeting fructose metabolism in the heart rescues diastolic function in cardiometabolic disease

      P1.33 · Jihoon Nah (Cheongju-si, Republic of Korea)
      Inhibition of autosis by reinforcing the nuclear membrane protects the heart against ischemia-reperfusion injury

      P1.34 · Tomoe Y. Nakamura-Nishitani (Wakayama, Japan)
      Mitochondria as architects of cardiac calcium-structure coupling

      P1.35 · Geena Varghese Paramel (Örebro, Sweden)
      Cardiac spheroids as a human model for inflammation induced cardiac dysfunction

      P1.36 · Liming Pei (Philadelphia, PA, U.S.A.)
      A spatiotemporal multidimensional human heart atlas reveals underlying mechanisms of human heart disease progression

      P1.37 · Tai Sada (Kobe, Japan)
      Spatial dynamics of metabolism and proliferation in postnatal rodent and primate hearts

      P1.38 · Nandini Sanoujam (Daegu, Republic of Korea)
      The NQO1-AMPK axis regulates energy balance and metabolic homeostasis in diet-induced obesity

      P1.39 · Michael Schwarzer (Jena, Germany)
      Etiology-dependent mitochondrial loss and enhanced inflammatory activation across stages of advanced heart failure

      P1.40 · Klaudia Stawarska (Gdańsk, Poland)
      An integrated human cardiac slice platform for functional and metabolic phenotyping in cardiotoxicity research

      P1.41 · Xiaonkang Tang (Okazaki, Japan)
      Hypoxia-electrophile crosstalk promotes cardiac stress adaptation via sulfide accumulation

      P1.42 · Kevin Tran (Parkville, Australia)
      Evaluating Cardiorenal Protection of Mineralocorticoid Receptor Antagonism (MRA) and Sodium-Glucose Cotransporter 2 Inhibition (SGLT2i) Combination Therapy in Type 2 Diabetes Mellitus (T2DM)

      P1.43 · Natsuko Tsurudome (Osaka, Japan)
      Lymphatic endothelial cell senescence is a potential pathological mechanism linking atrial fibrillation and ventricular remodeling

      P1.44 · Jishamol Thazhath Veettil (Örebro, Sweden)
      Atherosclerotic plaque crystals induce endothelial dysfunction

      P1.45 · Di Wu (Fukuoka, Japan)
      TRPC3-NADPH oxidase 2 protein complex formation accelerates disuse muscle atrophy

      P1.46 · Jiyoung Yoon (Gwangju, Republic of Korea)
      Title: Empagliflozin mitigates lobeglitazone-associated cardiac, hepatic and body-weight adverse effects in db/db mice.

      P1.47 · Martin E. Young (Birmingham, AL, U.S.A.)
      Cardiomyocyte PER2 regulates cardiac metabolism and function

      P1.48 · Aaron Jiashuo Zhang (Oxford, United Kingdom)
      Epigenetic reprogramming via dysregulated H3K9 trimethylation drives cardiac energetic dysfunction in type 2 diabetes

      P1.49 · Zhenyi Zhao (Orsay, France)
      Assessing the effects of Nicotinamide Riboside (NR) combined with  exercise training  in heart failure with preserved ejection fraction

      P1.50 · Nikole J Byrne (Graz, Austria)
      NAD+ repletion improves hepatic lipid accumulation and adipose tissue inflammation in atherosclerosis

    • Poster Session II • Wednesday, 28 October • 15:45-17:45

      P2.1 · Rita Alonaizan (Riyadh, Saudi Arabia)
      A balanced circadian glycolytic rhythm drives cardiomyocyte cell cycle progression during fish heart regeneration

      P2.2 · Kohei Ariyoshi (Fukuoka, Japan)
      The analysis of the relationship between Filamin and mitochondrial function in the heart

      P2.3 · Tin May Aung (Osaka, Japan)
      PCPE-1 promotes renal fibrosis with aging and cardiorenal syndrome in chronic kidney disease

      P2.4 · Tayla R. Bishop (Melbourne, Australia)
      Divergent sex- and ligand-specific effects of soluble guanylate cyclase (sGC) modulators on blood pressure and exercise capacity in a preclinical mouse model of heart failure with preserved ejection fraction (HFpEF)

      P2.5 · Charlotte Blavier (Zaventem, Belgium)
      The platelet lipidome in HFpEF: a metabolic signature of platelet-driven pathophysiology

      P2.6 · Ellen Budiono (Cheonan, Republic of Korea)
      Dendritic cell-specific DPP4 deletion ameliorates cardiac dysfunction and fibrosis in a murine model of obesity-related HFpEF

      P2.7 · Stepheny C. de Campos Zani (Edmonton, Canada)
      Short-term ketogenic diets decrease body weight independently of dietary fat source and do not improve metabolic outcomes in obese mice

      P2.8 · Marcos Castro Guarda (Oxford, United Kingdom)
      Targeting fumarate signalling as a novel mechanism of cardiac remodelling during ischaemia

      P2.9 · Olivia Conway (Oxford, United Kingdom)
      Transcriptomic phenotyping of human cardiac adipose depots and myocardium reveals T2DM-associated remodelling in cardiovascular disease

      P2.10 · Sanushi Thamasha Dambure Vithanachchi (London, United Kingdom)
      Multi-omics profiling of the molecular trajectory of cardiac remodelling in CKD-associated heart failure with preserved ejection fraction (HFpEF). 

      P2.11 · Jayd T. Dayaram (Auckland, New Zealand)
      Uncovering novel mechanism-directed therapies for cardiometabolic heart failure with preserved ejection fraction

      P2.12 · Miles De Blasio (Melbourne, Australia)
      The small-molecule adiponectin receptor agonist AdipoRon reduces cardiac ceramide levels and improves cardiac function in a mouse model of type-2 diabetes

      P2.13 · Kaitlyn M.J.H. Dennis (Oxford, United Kingdom)
      Development of an ex vivo human precision cut liver slice model to probe hepatocyte nutrient metabolism

      P2.14 · Eliano dos Santos (London, United Kingdom)
      PGAM2 is a critical metabolic node in heart failure progression

      P2.15 · Dongxiao Fan (Hong Kong, China)
      Investigating mitochondria-mediated integrated stress response in abdominal aortic aneurysm

      P2.16 · Luís F. Grilo (Cantanhede, Portugal)
      In utero maternal undernutrition reprograms the cardiac bioenergetic trajectory of aging

      P2.17 · Ayeong Han (Hwasun, Republic of Korea)
      Loss of p300/CBP-associated factor exacerbates pathological cardiac remodeling through impaired CAMKK2 acetylation

      P2.18 · Mobina Heidari Darmani (Edmonton, Canada)
      Effect of aging and obesity on metabolic flexibility and markers of mitochondrial metabolism

      P2.19 · Leanne Hodson (Oxford, United Kingdom)
      Divergent effects of dietary fatty acids on the hepatic–cardiac axis: evidence from human in vivo and in vitro cell models

      P2.20 · Koichi Isayama (Fukuoka, Japan)
      Sulfiredoxin protects against chronic kidney disease-induced diastolic dysfunction by suppressing glutathionylation and TGF-β/Smad signaling

      P2.21 · Agata Jedrzejewska (Gdansk, Poland)
      Altered NAD⁺ metabolism and the effects of NAD⁺ boosting in hypertensive heart failure

      P2.22 · Dona Josh (Oxford, United Kingdom)
      Sex differences underpin differential metabolic and cardiac functional responses to type 2 diabetes

      P2.23 · Se Yong Jung (Seoul, Republic of Korea)
      Development of an ester-linked adhesive vasodilator to prevent Intimal hyperplasia and arteriovenous fistula failure

      P2.24 · Qutuba Karwi (St. John's, Canada)
      Decoding ventricular differences: UCP2 as a modulator of cardiac oxidative Metabolism and Ca²⁺ homeostasis

      P2.25 · Hyoung Kyu Kim (Busan, Republic of Korea)
      Empagliflozin Confers Cardioprotection in Diabetic Cardiomyopathy via Direct JNK3 Binding and c-Jun/c-Fos Uncoupling

      P2.26 · Oliwia Krol (Gdansk, Poland)
      Caloric restriction improves vascular purinergic metabolism and cardiac energetics in aging spontaneously hypertensive rats

      P2.27 · Veronique A. Lacombe (Stillwater, OK, U.S.A.)
      Cardiac structure and function, but not insulin dysregulation, predict atrial fibrillation susceptibility in a large animal model

      P2.28 · Benjamin Lauzier (Nantes, France)
      Over two decades of O-GlcNAc study: though for the mind

      P2.29 · Yun-Gyeong Lee (Hwasun, Republic of Korea)
      Ret finger protein deficiency attenuates adipogenesis in mice with high fat diet-induced obesity

      P2.30 · Norika Liu (Kumamoto, Japan)
      Mechanisms of cardiac morphogenesis and homeostasis regulated by macrophages

      P2.31 · Kasturi Markandran (Singapore, Singapore)
      Unexpected cardioprotection in doxorubicin-treated mice during sepsis: DENND4A-RAB10 axis as a potential mediator

      P2.32 · Xinya Mi (Fukuoka, Japan)
      Beneficial effect of TRPC6 channel-mediated Zn2+ influx in mouse hearts

      P2.33 · Yuya Nakamura (Fukuoka, Japan)
      Cysteine persulfide/polysulfide poteomics reveals depolysulfidation of mitochondrial proteins in failing mouse hearts

      P2.34 · Akiyuki Nishimura (Okazaki, Japan)
      Thiol-based redox modification of proteins for mitochondrial quality and cardiac robustness

      P2.35 · Hye Rim Park (Seoul, Republic of Korea)
      Loss of compensatory Ca2+-dependent contractile regulation during the transition from right ventricular hypertrophy to failure in a rat model of pulmonary arterial hypertension

      P2.36 · Thomas Pulinilkunnil (Saint John, Canada)
      SAR1 proteins remodel lipid droplet turnover and oxidative metabolism in muscle

      P2.37 · Wataru Saitoh (Osaka, Japan)
      N6-methyladenosine regulator RBM15B protects against adverse cardiac remodeling under pressure overload through RNA modification

      P2.38 · Michio Sato (Kumamoto, Japan)
      A Hypertensive Stress–Based Mouse Model Reveals Immune–Metabolic Rewiring in Non-Obese HFpEF

      P2.39 · Shigeki Shichida (Saga, Japan)
      Distinct atrial remodeling phenotypes in non-AF patients and their association with aging and metabolism: an exploratory transcriptomic study

      P2.40 · Eline Stukkens (Brussels, Belgium)
      Hyperacetylation comes first: an early event preceding cardiac insulin resistance and functional decline in diet-induced diabetic cardiomyopathy

      P2.41 · Shuya Tokumoto (Fukuoka, Japan)
       Adipose-Derived Stem Cells Attenuate Pressure Overload-Induced Cardiac Remodeling via DKK3-Mediated Suppression of MAPK Signaling

      P2.42 · Nguyen Tu Tran (Seoul, Republic of Korea)
      GDH-driven anaplerosis restores diastolic function in HFpEF mice by refueling the TCA cycle

      P2.43 · Kensuke Tsushima (Los Angeles, CA, U.S.A.)
      Analyzing the spatial dynamics of myocardial mitochondria, organelles and signal transduction using the tissue CLEM technique.

      P2.44 · Hideki Uosaki (Shimotsuke, Japan)
      A patient-derived iPSC library of mitochondrial cardiomyopathy identified beneficial effects of taurine to KARS mutations

      P2.45 · Yang Kevin Xiang (Los Angeles, CA, U.S.A.)
      GPCRs promotes S-nitrosylation-dependent activation of protein kinase A in heart and fat

      P2.46 · Jae Boum Youm (Busan, Republic of Korea)
      Diabetic metabolic remodeling as a gate for post-infarct reentry: core size × border-zone extent

      P2.47 · Megan Young (London, United Kingdom)
      Does NLRP3 couple metabolic stress to cardiac dysfunction in diabetic cardiomyopathy?

      P2.48 · Jianhua Zhang (Birmingham, AL, U.S.A.)
      Beyond cardiomyocytes: heterogeneity of cardiac mitophagy in basal and stress conditions with endothelial cells as major responders

      P2.49 · Liuchenzi Zhou (Okazaki, Japan)
      Communication between cardiac fibroblasts and cardiomyocytes via extracellular vesicles

      P2.50 · Zhihong Li (Osaka, Japan)
      Senoherb induces senolysis through inhibition of the anti–cell death membrane protein